Isolated Anti-HBc: Significance and Management
Identifieur interne : 000025 ( France/Analysis ); précédent : 000024; suivant : 000026Isolated Anti-HBc: Significance and Management
Auteurs : Florian Moretto ; François-Xavier Catherine ; Clémentine Esteve ; Mathieu Blot [France] ; Lionel Piroth [France]Source :
- Journal of Clinical Medicine [ 2077-0383 ] ; 2020.
Abstract
Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing debate regarding the management of patients with IAHBc. Herein, we summarize the current guidelines and the newest evidence. The frequency of IAHBc is variable, with a higher prevalence in some populations, such as persons living with HIV and others immunocompromised patients. The risk of HBV reactivation depends on host factors (including immunosuppression) and viral factors. It is now well established that immunocompromised patients can be classified into three groups for risk according to the type of immunosuppression and/or treatment. In patients at high risk, HBV therapy has to be considered systematically. In patients at moderate risk, the decision is based on the level of HBV DNA (preemptive treatment or monitoring and vaccination). In patients with low risk, HBV vaccination is another possible approach, although further studies are needed to assess the type of preemptive strategy.
Url:
DOI: 10.3390/jcm9010202
PubMed: 31940817
PubMed Central: 7019847
Affiliations:
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PMC:7019847Le document en format XML
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xml:lang="en"><p>Hepatitis B virus (HBV) infection is prevalent worldwide and is associated with dramatic levels of morbidity and mortality. Isolated anti-HBc (IAHBc) is a particular serological pattern that is commonly found in immunocompromised patients. There is ongoing debate regarding the management of patients with IAHBc. Herein, we summarize the current guidelines and the newest evidence. The frequency of IAHBc is variable, with a higher prevalence in some populations, such as persons living with HIV and others immunocompromised patients. The risk of HBV reactivation depends on host factors (including immunosuppression) and viral factors. It is now well established that immunocompromised patients can be classified into three groups for risk according to the type of immunosuppression and/or treatment. In patients at high risk, HBV therapy has to be considered systematically. In patients at moderate risk, the decision is based on the level of HBV DNA (preemptive treatment or monitoring and vaccination). In patients with low risk, HBV vaccination is another possible approach, although further studies are needed to assess the type of preemptive strategy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Ait Goughoulte, M" uniqKey="Ait Goughoulte M">M. Ait-Goughoulte</name></author><author><name sortKey="Lucifora, J" uniqKey="Lucifora J">J. Lucifora</name></author><author><name sortKey="Zoulim, F" uniqKey="Zoulim F">F. Zoulim</name></author><author><name sortKey="Durantel, D" uniqKey="Durantel D">D. Durantel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, J J" uniqKey="Chang J">J.J. Chang</name></author><author><name sortKey="Mohtashemi, N" uniqKey="Mohtashemi N">N. Mohtashemi</name></author><author><name sortKey="Bhattacharya, D" uniqKey="Bhattacharya D">D. 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Kapetanovic</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne</li><li>Bourgogne-Franche-Comté</li></region><settlement><li>Dijon</li></settlement></list><tree><noCountry><name sortKey="Catherine, Francois Xavier" sort="Catherine, Francois Xavier" uniqKey="Catherine F" first="François-Xavier" last="Catherine">François-Xavier Catherine</name><name sortKey="Esteve, Clementine" sort="Esteve, Clementine" uniqKey="Esteve C" first="Clémentine" last="Esteve">Clémentine Esteve</name><name sortKey="Moretto, Florian" sort="Moretto, Florian" uniqKey="Moretto F" first="Florian" last="Moretto">Florian Moretto</name></noCountry><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Blot, Mathieu" sort="Blot, Mathieu" uniqKey="Blot M" first="Mathieu" last="Blot">Mathieu Blot</name></region><name sortKey="Piroth, Lionel" sort="Piroth, Lionel" uniqKey="Piroth L" first="Lionel" last="Piroth">Lionel Piroth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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